Gliomas form a very heterogeneous class of tumors that present with different growth phenotypes, ranging from invasive lesions without notable mass-effect to strongly displacing lesions that induce mechanical stresses and result in healthy-tissue deformation, midline shift or herniation. Recent studies have shown the importance of biomechanical forces in shaping the tumour microenvironment, contributing to tumour progression and treatment response. Forces building up
Project Members D. Abler, PhDMSCA-Fellow at University of Bern and City of Hope Prof. P. Büchler, PhD Group head of Computational Bioengineering, ARTORG at University of Bern Prof. R. Rockne, PhDDirector of Division of Mathematical Oncology, Beckman Research Institute at City of Hope Project Institutes University of Bern (Switzerland) ARTORG Center for Biomedical Engineering Research, Computational Bioengineering group City of Hope (USA) Beckman Research Institute,
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Journal Articles P. Sahoo, Y. Xin, D. Abler, D. Maestrini, V. Adhikarla, D. Frankhouser, H. Cho, V. Machuca, D. Wang, M. Barish, M. Gutova, S. Branciamore, C. E. Brown, R. C. Rockne Mathematical Deconvolution of CAR T-Cell Proliferation and Exhaustion from Real-Time Killing Assay Data. In: Journal of The Royal Society Interface 17, no. 162 (01/2020): 10.1098/rsif.2019.0734. M. Kingsmore, A. Vaccari, D. Abler, S. X.
Project Summary Duration: 36 months (start date: June 2017) Acronym: GlimS Full Title: Patient-specific tumour growth model for quantification of mechanical ‘markers’ in malignant gliomas: Implications for treatment outcomes. Programme: Horizon 2020 Programme of the European Commission, Marie Skłodowska-Curie Actions 2016-2017, H2020-MSCA-IF-2016 Project ID: 209085 Abstract Gliomas are the most frequent primary brain tumours in adults (70%) with Glioblastoma multiforme